Representations of rational Cherednik algebras of G(m,r,n) in positive characteristic

We study lowest-weight irreducible representations of rational Cherednik algebras attached to the complex reflection groups G(m,r,n) in characteristic p. Our approach is mostly from the perspective of commutative algebra. By studying the kernel of the contravariant bilinear form on Verma modules, we obtain formulas for Hilbert series of irreducible representations in a number of cases, and present conjectures in other cases. We observe that the form of the Hilbert series of the irreducible representations and the generators of the kernel tend to be determined by the value of n modulo p, and are related to special classes of subspace arrangements. Perhaps the most novel (conjectural) discovery from the commutative algebra perspective is that the generators of the kernel can be given the structure of a "matrix regular sequence" in some instances, which we prove in some small cases.Comment: 23 pages; v2: clarified statement of Lemma 3.

Business development trends and analysis for the data networking market

Thesis (S.M. in Engineering and Management)--Massachusetts Institute of Technology, Engineering Systems Division, System Design and Management Program, 2011.Cataloged from PDF version of thesis.Includes bibliographical references (p. 89-96).The Internet has come a long way after the widely reported invention by Sandra Lerner and Leonard Bosack of the router, a device that can transmit data from one network to another based on certain protocols and principles. Despite a slow start in the mid 1980s, the Internet has emerged as one of the primary means of communication for people of all walks of life. Sophisticated, network-aware applications that integrate data, voice and video have helped fuel this growth. This thesis examines the latest technology trends and historical developments in various market segments of the Internet. Using technology trends as a backdrop, it analyzes business development at Cisco Systems, Inc., a major player in all Internet market segments. Well-known tools and concepts such as the Familiarity Matrix and Technology S-curve are used for case studies of business development at Cisco. Business Development is almost always a high-stakes endeavor requiring keen insight on both financial and strategy fronts. What are good strategies for corporate entrepreneurship? What are the challenges in business development by way of acquisitions? Will cyber anonymity continue to make us lonely and distanced, or will there be a new breed of Internet applications that will genuinely bring people closer? These are some of the questions this thesis explores, drawing on the wisdom and experience of industry experts.by Devadas V. Patil.S.M.in Engineering and Managemen

Identification of XMRV Infection-Associated microRNAs in Four Cell Types in Culture

INTRODUCTION: XMRV is a gammaretrovirus that was thought to be associated with prostate cancer (PC) and chronic fatigue syndrome (CFS) in humans until recently. The virus is culturable in various cells of human origin like the lymphocytes, NK cells, neuronal cells, and prostate cell lines. MicroRNAs (miRNA), which regulate gene expression, were so far not identified in cells infected with XMRV in culture. METHODS: Two prostate cell lines (LNCaP and DU145) and two primary cells, Peripheral Blood Lymphocytes [PBL] and Monocyte-derived Macrophages [MDM] were infected with XMRV. Total mRNA was extracted from mock- and virus-infected cells at 6, 24 and 48 hours post infection and evaluated for microRNA profile in a microarray. RESULTS: MicroRNA expression profiles of XMRV-infected continuous prostate cancer cell lines differ from that of virus-infected primary cells (PBL and MDMs). miR-193a-3p and miRPlus-E1245 observed to be specific to XMRV infection in all 4 cell types. While miR-193a-3p levels were down regulated miRPlus-E1245 on the other hand exhibited varied expression profile between the 4 cell types. DISCUSSION: The present study clearly demonstrates that cellular microRNAs are expressed during XMRV infection of human cells and this is the first report demonstrating the regulation of miR193a-3p and miRPlus-E1245 during XMRV infection in four different human cell types

The Façade Wall: a Focus on the Green Architecture of Laurie Baker’s Houses

I would like to thank architect Sajan for his support and putting me in touch with the three houseowners and for his suggestion to study on Baker’s use of pattern in his building vocabulary. Architect Sajan was trained under Laurie Baker and continues his work under the aegis of Costford. I would like to thank the three houseowners – Mrs Narayanan, Mr George and Mrs Subrahmaniam – for their support and giving me their valuable time. I would like to thank Mr Anil Kumar of Laurie Baker Centre for giving me permission to use images from the book Untold Stories published by Laurie Baker Centre.This paper is an attempt to illustrate ‘green’ strategies Laurie Baker uses, in particular with respect to passive design principles as applied to houses. Green architecture is holistic and socially sensitive as it, in addition to being environmentally conscious, addresses the well-being of its users. This paper will focus on the method of harvesting ‘green’ ideals with respect to the architecture of the façade wall in Laurie Baker’s houses. Three houses designed by Baker in the 1990s in Trivandrum, Kerala will be studied. The discussion will show that Baker’s façade design strategies represent innovative solutions for facade designs built on low technology with derivations from the local vernacular in a contemporary architectural language. In the larger context of architecture of sustainability and green architecture, Baker’s approach, it will be shown, is essentially humanist and presents a way forward to establishing identity through place and an understanding of culture. In a digital era, which challenges identity and encourages notions of connectivity in a global sense, Baker’s architecture, it will be proposed, promotes green principles in making significant the value of the local and in the credence it gives to the end user and the craftsman in a singularly unique architectural language

In situ approach for rapid characterization to aid on farm conservation of coconut germplasm - A case study of two ecotypes from West coast of India

Characterization and evaluation of coconut germplasm have conventionally been undertaken in ex situ gene banks, which take a minimum duration of fifteen years. On the other hand, utilization of coconut populations in situ can effectively reduce the time required for characterization of the populations. Hence, a concept to make a paradigm shift in the existing approach of coconut germplasm characterization is advocated in this study with a view to broaden the conservation base and facilitate inclusion of identified diverse ecotypes. The methodology has been applied to identify, locate and characterize two tall coconut ecotypes viz., Bedakam and Kuttiyadi, from northern Kerala. Agronomic traits, viz., higher number of nuts per palm, higher copra content and better performance under marginal management conditions along with adaptation to the environment, were the major reasons for preference of these ecotypes among the farmers. Comparison of the two ecotypes revealed that the traits, trunk girth, length of internode, number of leaves, number of bunches with nuts, number of nuts, shell weight, husked fruit weight and fruit weight were higher in Kuttiyadi than in Bedakam ecotype. On the other hand, number of leaf scars per meter, length of inflorescence, fruit breadth, husk weight, nut cavity volume and copra weight were higher in Bedakam compared to Kuttiyadi ecotype. Relevance, utility and importance of the study are discussed from the perspective of effective utilization of the coconut diversity in situ and their possible further use in coconut improvement efforts through conservation strategies

The <i>N</i>-myristoylome of <i>Trypanosoma cruzi</i>

Protein N-myristoylation is catalysed by N-myristoyltransferase (NMT), an essential and druggable target in Trypanosoma cruzi, the causative agent of Chagas’ disease. Here we have employed whole cell labelling with azidomyristic acid and click chemistry to identify N-myristoylated proteins in different life cycle stages of the parasite. Only minor differences in fluorescent-labelling were observed between the dividing forms (the insect epimastigote and mammalian amastigote stages) and the non-dividing trypomastigote stage. Using a combination of label-free and stable isotope labelling of cells in culture (SILAC) based proteomic strategies in the presence and absence of the NMT inhibitor DDD85646, we identified 56 proteins enriched in at least two out of the three experimental approaches. Of these, 6 were likely to be false positives, with the remaining 50 commencing with amino acids MG at the N-terminus in one or more of the T. cruzi genomes. Most of these are proteins of unknown function (32), with the remainder (18) implicated in a diverse range of critical cellular and metabolic functions such as intracellular transport, cell signalling and protein turnover. In summary, we have established that 0.43–0.46% of the proteome is N-myristoylated in T. cruzi approaching that of other eukaryotic organisms (0.5–1.7%)

First enantioseparation and circular dichroism spectra of Au38 clusters protected by achiral ligands

Bestowing chirality to metals is central in fields such as heterogeneous catalysis and modern optics. Although the bulk phase of metals is symmetric, their surfaces can become chiral through adsorption of molecules. Interestingly, even achiral molecules can lead to locally chiral, though globally racemic, surfaces. A similar situation can be obtained for metal particles or clusters. Here we report the first separation of the enantiomers of a gold cluster protected by achiral thiolates, Au38(SCH2CH2Ph)24, achieved by chiral high-performance liquid chromatography. The chirality of the nanocluster arises from the chiral arrangement of the thiolates on its surface, forming 'staple motifs'. The enantiomers show mirror-image circular dichroism responses and large anisotropy factors of up to 4×10−3. Comparison with reported circular dichroism spectra of other Au38 clusters reveals that the influence of the ligand on the chiroptical properties is minor

Selective Inhibitors of Protozoan Protein N-myristoyltransferases as Starting Points for Tropical Disease Medicinal Chemistry Programs

Inhibition of N-myristoyltransferase has been validated pre-clinically as a target for the treatment of fungal and trypanosome infections, using species-specific inhibitors. In order to identify inhibitors of protozoan NMTs, we chose to screen a diverse subset of the Pfizer corporate collection against Plasmodium falciparum and Leishmania donovani NMTs. Primary screening hits against either enzyme were tested for selectivity over both human NMT isoforms (Hs1 and Hs2) and for broad-spectrum anti-protozoan activity against the NMT from Trypanosoma brucei. Analysis of the screening results has shown that structure-activity relationships (SAR) for Leishmania NMT are divergent from all other NMTs tested, a finding not predicted by sequence similarity calculations, resulting in the identification of four novel series of Leishmania-selective NMT inhibitors. We found a strong overlap between the SARs for Plasmodium NMT and both human NMTs, suggesting that achieving an appropriate selectivity profile will be more challenging. However, we did discover two novel series with selectivity for Plasmodium NMT over the other NMT orthologues in this study, and an additional two structurally distinct series with selectivity over Leishmania NMT. We believe that release of results from this study into the public domain will accelerate the discovery of NMT inhibitors to treat malaria and leishmaniasis. Our screening initiative is another example of how a tripartite partnership involving pharmaceutical industries, academic institutions and governmental/non-governmental organisations such as Medical Research Council and Wellcome Trust can stimulate research for neglected diseases

Hypothermia for moderate or severe neonatal encephalopathy in low-income and middle-income countries (HELIX): a randomised controlled trial in India, Sri Lanka, and Bangladesh

Background: Although therapeutic hypothermia reduces death or disability after neonatal encephalopathy in high-income countries, its safety and efficacy in low-income and middle-income countries is unclear. We aimed to examine whether therapeutic hypothermia alongside optimal supportive intensive care reduces death or moderate or severe disability after neonatal encephalopathy in south Asia. Methods: We did a multicountry open-label, randomised controlled trial in seven tertiary neonatal intensive care units in India, Sri Lanka, and Bangladesh. We enrolled infants born at or after 36 weeks of gestation with moderate or severe neonatal encephalopathy and a need for continued resuscitation at 5 min of age or an Apgar score of less than 6 at 5 min of age (for babies born in a hospital), or both, or an absence of crying by 5 min of age (for babies born at home). Using a web-based randomisation system, we allocated infants into a group receiving whole body hypothermia (33·5°C) for 72 h using a servo-controlled cooling device, or to usual care (control group), within 6 h of birth. All recruiting sites had facilities for invasive ventilation, cardiovascular support, and access to 3 Tesla MRI scanners and spectroscopy. Masking of the intervention was not possible, but those involved in the magnetic resonance biomarker analysis and neurodevelopmental outcome assessments were masked to the allocation. The primary outcome was a combined endpoint of death or moderate or severe disability at 18–22 months, assessed by the Bayley Scales of Infant and Toddler Development (third edition) and a detailed neurological examination. Analysis was by intention to treat. This trial is registered with ClinicalTrials.gov, NCT02387385. Findings: We screened 2296 infants between Aug 15, 2015, and Feb 15, 2019, of whom 576 infants were eligible for inclusion. After exclusions, we recruited 408 eligible infants and we assigned 202 to the hypothermia group and 206 to the control group. Primary outcome data were available for 195 (97%) of the 202 infants in the hypothermia group and 199 (97%) of the 206 control group infants. 98 (50%) infants in the hypothermia group and 94 (47%) infants in the control group died or had a moderate or severe disability (risk ratio 1·06; 95% CI 0·87–1·30; p=0·55). 84 infants (42%) in the hypothermia group and 63 (31%; p=0·022) infants in the control group died, of whom 72 (36%) and 49 (24%; p=0·0087) died during neonatal hospitalisation. Five serious adverse events were reported: three in the hypothermia group (one hospital readmission relating to pneumonia, one septic arthritis, and one suspected venous thrombosis), and two in the control group (one related to desaturations during MRI and other because of endotracheal tube displacement during transport for MRI). No adverse events were considered causally related to the study intervention. Interpretation: Therapeutic hypothermia did not reduce the combined outcome of death or disability at 18 months after neonatal encephalopathy in low-income and middle-income countries, but significantly increased death alone. Therapeutic hypothermia should not be offered as treatment for neonatal encephalopathy in low-income and middle-income countries, even when tertiary neonatal intensive care facilities are available. Funding: National Institute for Health Research, Garfield Weston Foundation, and Bill & Melinda Gates Foundation. Translations: For the Hindi, Malayalam, Telugu, Kannada, Singhalese, Tamil, Marathi and Bangla translations of the abstract see Supplementary Materials section